Edward O'Brien

Graduate Student

I am a fifth year doctoral candidate in the Bioinformatics and Systems Biology graduate program at the University of California, San Diego.

My thesis is titled: "Optimality principles and tradeoffs in the evolution and regulation of Escherichia coli".

I am working on several projects involving experimental evolution of E. coli. In these projects, I am analyzing genomic, transcriptomic, proteomic, and metabolomic data to identify the molecular causes of increased fitness and the general mechanisms and tradeoffs observed in adaptive evolution. In another project, I am dissecting the optimality principles that have naturally evolved in the regulation of E. coli's proteome under varying environments. In all projects, I use a genome-scale model for E. coli I developed that integrates it's metabolic and gene expression networks to aide in analysis.

See my Google Scholar profile for my publications.


2010 B.S. (Mathematics, Engineering Science) Tufts University, Medford MA

Contact Information

Email Address: ejobrien@ucsd.edu



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