Go to the openCOBRA webpage.
A software package running in the MATLAB environment which allows for quantitative prediction of cellular behavior using a constraint-based approach. Becker, S. et al., "Quantitative prediction of cellular metabolism with constraint-based models: The COBRA Toolbox", Nat. Protoc 2, 727-738 (2007).
Schellenberger J, Que R, Fleming RMT, Thiele I, Orth JD, Feist AM, Zielinski DC, Bordbar A, Lewis NE, Rahmanian S et al., Quantitative prediction of cellular metabolism with constraint-based models: the COBRA Toolbox v2.0 Nat Protoc 6(9):1290-307 (2011).
Ebrahim A, Lerman JA, Palsson BO, Hyduke DR. COBRApy: COnstraints-Based Reconstruction and Analysis for Python BMC Syst Bio 7:74 (2013).