Making biological phenomena predictable and to simulate entire cellular systems in the computer would be beneficial for biotechnological production of medication and personalized medicine. The genome-scale development of holistic, detailed, and reliable computer models incorporating physico-chemical constraints can only be feasible by using precise automated methods. This project aims to extend approaches for model creation. The effectiveness of the method are being experimentally validated on large-scale metabolic data. To this end, the project "automated multi-level modeling of biological systems considering physico-chemical constraints" (AMBiCon) has been established as an international collaboration project between the University of California, San Diego, and the University of Tuebingen, Tübingen, Germany.